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KMID : 0378020060490110039
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New Medical Journal
2006 Volume.49 No. 11 p.39 ~ p.45
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Comparison of Effectiveness of Doxapram, Meperidine and Clonidine on Postanesthetic Shivering
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Bae Sang-Chul
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Abstract
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Background: Although post-anesthetic shivering may be a temporary phenomenom, it leads to detrimental effects. Because all shivering patients feel uncomfortable and increase oxygen consumption, various attempts have been made to prevent its occurrence or to control it. Among the pharmacological methods of treating shivering, meperidine has been known to be the most effective. This study was designed to evaluate wheather there was any difference among doxapram, meperidine, clonidine and normal saline in the treatment of postanesthetic shivering.
Methods: Sixty patients (ASA class 1 or 2) who showed postoperative shivering were randomly assigned four groups (n=15): Normal saline group: normal saline 5 ml, Doxapram group: doxapram 1.5mg/kg, Meperidine group: meperidine 25 mg, Clonidine group: clonidine 2.5 ㎍/kg. And all patients received routine care: oxygen by T-piece and heat-reflective blanketrol? (Cincinati Subzero, U.S.A.). Evaluation of the state of shivering was done every 5 minutes from the beginning of the treatment by the same investigator who had injected the drugs intravenously for treatment of shivering. The age, sex, weight and duration of surgery were recorded.
Results: There were no significant statistical differences in age, sex, weight and duration of surgery among the four groups. By 5 minutes, 80% of doxapram group and 40% of meperidine group had stopped shivering. By 10 minutes, 90% of doxapram group and 70% of meperidine group had stopped shivering. But in normal saline group, only 20% had
stopped shivering by 10 minutes.
Conclusion: We conclude that doxapram, meperidine and clonidine are effective on post-anesthetic shivering. In case of patient with respiratory depression, doxapram is especially effective because it stimulates the respiratory center.
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KEYWORD
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Analeptics, doxapram, Analgesics, meperidine, Antihypertensive, clonidine, Complication, post-anesthetic shivering
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